Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice.

Masayoshi Kukida,Naofumi Amioka,Dien Ye,Hui Chen,Jessica J Moorleghen,Ching-Ling Liang,Deborah A Howatt,Yuriko Katsumata,Motoko Yanagita,Hisashi Sawada,Alan Daugherty,Hong S Lu

Frontiers in cardiovascular medicine（2023）

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摘要

Whole-body AT1R inhibition reduced atherosclerosis equivalently in both male and female mice; however, PTC-specific manipulation of the RAS components had no effects on hypercholesterolemia-induced atherosclerosis.

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关键词

renin angiotensin system,renal proximal tubules,atherosclerosis

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