Synergistic effects of Boswellia serrata and Acmella oleracea extract combination for treating neuropathic pain in a preclinical model of spared nerve injury

Phytotherapy ResearchEarly View LETTER TO THE EDITOR Synergistic effects of Boswellia serrata and Acmella oleracea extract combination for treating neuropathic pain in a preclinical model of spared nerve injury Serena Boccella, Serena Boccella Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Contribution: Formal analysis, MethodologySearch for more papers by this authorConsalvo Mattia, Consalvo Mattia Division of Anesthesiology, Intensive Care and Pain Medicine, ICOT Polo Pontino Sapienza University of Rome, Rome, Italy Department of Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy Contribution: ConceptualizationSearch for more papers by this authorMichela Perrone, Michela Perrone Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Contribution: ​Investigation, MethodologySearch for more papers by this authorAndrea Maria Morace, Andrea Maria Morace Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Contribution: MethodologySearch for more papers by this authorElif Karabacak, Elif Karabacak Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Contribution: MethodologySearch for more papers by this authorFrancesca Guida, Francesca Guida Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Contribution: Writing - review & editingSearch for more papers by this authorSabatino Maione, Sabatino Maione Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Contribution: Conceptualization, Writing - review & editingSearch for more papers by this authorLivio Luongo, Corresponding Author Livio Luongo [email protected] [email protected] orcid.org/0000-0002-1949-2039 Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Correspondence Livio Luongo, Department of Experimental Medicine, University of Campania “L. Vanvitelli”, Naples, Italy. Email: [email protected] and [email protected] Contribution: Conceptualization, Supervision, Writing - original draftSearch for more papers by this author Serena Boccella, Serena Boccella Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Contribution: Formal analysis, MethodologySearch for more papers by this authorConsalvo Mattia, Consalvo Mattia Division of Anesthesiology, Intensive Care and Pain Medicine, ICOT Polo Pontino Sapienza University of Rome, Rome, Italy Department of Medico Surgical Sciences and Biotechnologies, Sapienza University of Rome, Rome, Italy Contribution: ConceptualizationSearch for more papers by this authorMichela Perrone, Michela Perrone Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Contribution: ​Investigation, MethodologySearch for more papers by this authorAndrea Maria Morace, Andrea Maria Morace Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Contribution: MethodologySearch for more papers by this authorElif Karabacak, Elif Karabacak Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Contribution: MethodologySearch for more papers by this authorFrancesca Guida, Francesca Guida Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Contribution: Writing - review & editingSearch for more papers by this authorSabatino Maione, Sabatino Maione Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Contribution: Conceptualization, Writing - review & editingSearch for more papers by this authorLivio Luongo, Corresponding Author Livio Luongo [email protected] [email protected] orcid.org/0000-0002-1949-2039 Department of Experimental Medicine, Università degli Studi della Campania “L. Vanvitelli”, Naples, Italy Correspondence Livio Luongo, Department of Experimental Medicine, University of Campania “L. Vanvitelli”, Naples, Italy. Email: [email protected] and [email protected] Contribution: Conceptualization, Supervision, Writing - original draftSearch for more papers by this author First published: 04 September 2023 https://doi.org/10.1002/ptr.8001 Serena Boccella and Consalvo Mattia shared the first Authorship. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES Boccella, S., Cristiano, C., Romano, R., Iannotta, M., Belardo, C., Farina, A., Guida, F., Piscitelli, F., Palazzo, E., Mazzitelli, M., Imperatore, R., Tunisi, L., De Novellis, V., Cristino, L., Di Marzo, V., Calignano, A., Maione, S., & Luongo, L. (2019). Ultra-micronized palmitoylethanolamide rescues the cognitive decline-associated loss of neural plasticity in the neuropathic mouse entorhinal cortex-dentate gyrus pathway. Neurobiology of Disease, 121, 106–119. https://doi.org/10.1016/j.nbd.2018.09.023 Boccella, S., Guida, F., De Logu, F., De Gregorio, D., Mazzitelli, M., Belardo, C., Iannotta, M., Serra, N., Nassini, R., de Novellis, V., Geppetti, P., Maione, S., & Luongo, L. (2019). Ketones and pain: Unexplored role of hydroxyl carboxylic acid receptor type 2 in the pathophysiology of neuropathic pain. 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