TMAO Promotes NLRP3 Inflammasome Activation of Microglia Aggravating Neurological Injury in Ischemic Stroke Through FTO/IGF2BP2.

Pengxin Ge,Huijie Duan,Chunrong Tao, Sensen Niu, Yiran Hu,Rui Duan,Aizong Shen,Yancai Sun,Wen Sun

Journal of inflammation research（2023）

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摘要

Our results demonstrated that TMAO promotes NLRP3 inflammasome activation of microglia aggravating neurological injury in ischemic stroke through FTO/IGF2BP2. These findings explained the molecular mechanism of TMAO aggravating ischemic stroke in detail and provided molecular mechanism for clinical treatment.

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关键词

nlrp3 inflammasome activation,microglia aggravating neurological injury,ischemic stroke,fto/igf2bp2

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