Radiation induces long-term muscle fibrosis and promotes a fibrotic phenotype in fibro-adipogenic progenitors.

Nicolas Collao,Donna D'Souza,Laura Messeiller,Evan Pilon,Jessica Lloyd,Jillian Larkin,Matthew Ngu,Alexanne Cuillerier,Alexander E Green,Keir J Menzies,Yan Burelle,Michael De Lisio

Journal of cachexia, sarcopenia and muscle（2023）

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摘要

Our study suggests that following juvenile radiation exposure, FAPs contribute to long-term skeletal muscle atrophy and fibrosis. These findings provide rationale for investigating FAP-targeted therapies to ameliorate the negative late effects of radiation exposure in skeletal muscle.

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关键词

Atrophy, Differentiation, Extracellular matrix, Mesenchymal progenitors, Metabolism, Myofibroblast, Skeletal muscle

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