Sphingomyelin synthase 2 foci determine sites of migrasome formation

NATURE CELL BIOLOGY（2023）

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摘要

Sphingomyelin synthase 2 foci assemble at the leading edge of the basal membrane in migrating cells, and these foci eventually become sites of migrasome formation. Conversion of ceramide to sphingomyelin spurs migrasome growth and preserves the structural integrity of these organelles.

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