Acid‐Controlled Regional Diverse Synthesis of CF3‐Containing Ketoimines and Application in the Construction of Bispiro[oxindole‐pyrrolidine‐benzothiophenone]s

Here described an acid-controlled regional diverse synthesized process of CF3-containing ketoimines by the condensation of benzo[b]thiophene-2,3-dione and 2,2,2-trifluoroethlamine. The imines obtained at either the 2-position or 3-position can be further used as substrates in asymmetric organocatalyzed [3+2]-cycloaddition reactions, leading to a library of regiodiverse bispiro-compounds with 85-96 % yield and 65-99 % ee.