Synthesis of 3-Aminoalkylated Indoles Using Heterogeneous MgFe 2 O 4 Nanoparticles under Microwave Irradiation in One-Pot Three-Component System

A series of 3-aminoalkylated indoles are efficiently synthesised in a one-pot three-component reaction under microwave irradiation. Magnesium ferrite (MgFe2O4) nanoparticles (10 mol%) have been used as heterogeneous catalyst, which may easily be recovered by application of an external magnet and the recovered catalyst can be reused at least for five runs without affecting the efficiency of the catalyst. The solvent-free protocol developed has advantages of less reaction time, high yields, and easy workup, and the protocol is applicable to various acid base sensitive functional groups present in the substrate. The reported methodology is highly suitable especially for primary amines in addition to secondary amines as one of the components.