Transition Metal and Base‐Free Electro‐Oxidative Regioselective Trifluoromethylation of Imidazo[1,2‐a]pyridines

A green electrochemical C(sp(2))-H trifluoromethylation of imidazo[1,2-a]pyridines by engaging Langlois' reagent is reported. This oxidative regioselective CF3-functionalization strategy operates under open atmosphere, in an undivided cell and at ambient temperature. Regioselective C-CF3 bond formation was achieved exclusively by applying this mild protocol exhibiting broad functional group compatibility affording the desired product up to 79% isolated yield. Mechanistic studies indicated a radical pathway for this electrochemical redox transformation.