Unexpected behavior of trisilanolisobutyl-poss, key compound in drug delivery systems, during mass spectrometry analysis

The structural investigation of trisilanolisobutyl-POSS, an important precursor for biocompatible materials and drug delivery systems, was performed by (+) ESI-OT-mass spectrometry, using multiple-stage fragmentation. This allowed us to obtain a series of MS1 - MS10 spectra, which are the first to be reported in the field of organosilicon chemistry and pharmaceutical additives. The structure of the fragmentation ions was fully assigned.