Protocol Using high-speed videography for objective and reproducible pain measurement on a mouse pain scale
STAR PROTOCOLS(2021)
摘要
Mouse models are essential for studying pain neurobiology and testing pain therapeutics. The reliance on assays that only measure the presence, absence, or frequency of a reflex have limited the reliability of preclinical pain studies. Our high-speed videography protocol overcomes this by projecting the discrete sub second kinematic behavioral features induced by hind paw stimulation onto a "mouse pain scale."This provides a more objective and robust pain measurement in mice by quantifying the quality of the stimulus-induced hind paw reflex. For complete details on the use and execution of this protocol, please refer to Abdus-Saboor et al. (2019).
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