One-pot synthesis of N-acylated ureas using phenyliodine (III) diacetate (PIDA) as N-acylation agent

An effective method was explored for the one-pot synthesis of N-acylated urea derivatives by the reaction of substituted isothiocyanatobenzenes, primary amines and PIDA (phenyliodine (III) diacetate) in one-pot manner. Mild reaction conditions, short reaction time, high efficiency and readily accessible materials are the features of this method, making suitable and alternative for the preparation of a variety of biologically or pharmaceutically active compounds.