Genetic and humoral characteristics of patients with moderate and severe hypertriglyceridemia without secondary etiology

Background and Aims: Background: Primary causes of hypertriglyceridemia (HTG) such as genetic defects i and autoimmune causes are rare. Certain genetic disorders such as LPL deficiency, Apo C-II deficiency, Apo A-V mutation, GPIHBP1 mutation, LFM1 mutation were related to HTG. Autoimmune disorders such as anibodies against apolipoprotein C-II, lipoprotein lipase, and GPIHBP1 were described as a rare cause of HTG.In this study we systematically examined genetic and humoral causes for patients with hypertriglyceridemia with no identifiable secondary causes.