LHPP in Glutamatergic Neurons of the Ventral Hippocampus Mediates Depression-like Behavior by Dephosphorylating CaMKIIα and ERK

Lvping Zhuang,Weijie Gao,Yanbing Chen,Wenting Fang,Hsuan Lo,Xiaoman Dai,Jie Zhang, Wanjing Chen,Qinyong Ye,Xiaochun Chen,Jing Zhang

Biological psychiatry（2023）

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摘要

These findings show evidence that LHPP contributes to the pathogenesis of depression via threonine and serine hydrolases, signifying LHPP as a potential therapeutic target in treating MDD patients.

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关键词

CaMKIIα,Depression,ERK,Esketamine,LHPP,Synaptic plasticity

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