Sedating antihistamine treatment with promethazine in patients with severe COPD with and without asthma: death and severe exacerbations in a nationwide register study.

Barbara Bonnesen,Valdemar Rømer,Sidse Graff Jensen,Jon Torgny Wilcke,Julie Janner, Jens Bak, Sofie Johansson,Christian B Laursen,Lars Pedersen,Josefin Eklof,Pradeesh Sivapalan,Jens-Ulrik Stæhr Jensen

European clinical respiratory journal（2023）

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摘要

Promethazine-treated patients with COPD had a concerning excess risk of a composite outcome of severe exacerbations and death from all causes compared to melatonin.

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关键词

severe copd,antihistamine treatment,promethazine,asthma,severe exacerbations

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