Factor XII promotes the thromboinflammatory response in a rat model of venoarterial extracorporeal membrane oxygenation

Mousa Kharnaf,Farhan Zafar,Spencer Hogue,Leah Rosenfeldt,Rachel L. Cantrell,Bal Krishan Sharma,Amelia Pearson,Cassandra Sprague,Daniel Leino,William A. Abplanalp,Wioleta M. Zelek,Keith R. McCrae,Young Jun Shim,David Morales,James Tweddell,Joseph E. Qualls,Joseph S. Palumbo

The Journal of Thoracic and Cardiovascular Surgery（2023）

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摘要

FXII initiates hemostatic system activation and key inflammatory sequelae in ECMO, suggesting that therapies targeting FXII could limit both thromboembolism and inopportune inflammatory complications in this setting.

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关键词

extracorporeal circulation,factor XII,neutrophil,complement,high molecular weight cleavage,inflammation

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