Sorafenib induces ferroptosis by promoting TRIM54-mediated FSP1 ubiquitination and degradation in hepatocellular carcinoma.

Hepatology communications（2023）

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摘要

Sorafenib facilitated the TRIM54-mediated FSP1 ubiquitination through the ERK pathway, thereby inducing ferroptosis in HCC cells.

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关键词

fsp1 ubiquitination,hepatocellular carcinoma,ferroptosis

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