Key enzyme in charge of ketone reabsorption of renal tubular SMCT1 may be a new target in diabetic kidney disease.

Zhenhong Guo,Feifei Zhong, Meng Hou,Jinlan Xie,A Zhong Zhang,Xinran Li,Yuan Li,Baocheng Chang,Juhong Yang

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association（2023）

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摘要

Decreased SMCT1 expression and its ketone reabsorption function play an important role in the occurrence of DKD. SMCT1 may be a new promising target in treating DKD.

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关键词

diabetic kidney disease, energy metabolic reprogramming, ketone body, renal tubular function, SMCT1

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