Esophageal Motility in Systemic Sclerosis Before and after Autologous Hematopoietic Cell Transplantation.

Systemic sclerosis (SSc) is associated with esophageal dysmotility. Autologous hematopoietic cell transplantation (HCT) results in improvement of skin tightness and lung function. Whether esophageal motility improves after HCT is unknown. Esophageal motility was studied using high-resolution esophageal manometry in 21 SSc patients before and at multiple time points after autologous HCT. Median posttransplant follow-up was 2 years (range, 6 months to 5 years). Prior to HCT, all 21 patients had abnormal motility—10 (48