Measurement of apixaban concentrations in different human biological fluids by UHPLC-MS/MS. Clinical pharmacokinetic application in a subject with chronic kidney disease and nonvalvular atrial fibrillation on haemodialysis.
Clinica chimica acta; international journal of clinical chemistry（2023）
摘要
The validated UHPLC-MS/MS procedures could help support a pharmacokinetic study in non-valvular atrial fibrillation subjects with chronic kidney disease undergoing haemodialysis and apixaban-based anticoagulant therapy.
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关键词
Apixaban,Plasma,Dialysate liquid,UHPLC-MS/MS,Urine
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