The Effect of Polymeric Binder Type and Concentration on Flow and Dissolution Properties of SMEDDS Loaded Mesoporous Silica-Based Granules

•Incorporation of higher molecular weight binders resulted in slower in vitro drug release from solid SMEDDS.•High binder concentration was related to faster in vitro drug release from solid SMEDDS.•Higher binder amount had favorable effect on flowability, although all SMEDDS granules were suitable for further tableting.•Both high-shear granulation and tableting had a slightly negative effect on drug release rate.•Povidone K30 was the best polymeric binder candidate for further research.