Budesonide, an anti-inflammatory drug, exacerbate clostridioides difficile colitis in mice.

Qianyun Lin,Zitong Li,Lei Lu,Hua Xu, Eddie Lou,Alyssa Chen, Dustin Sun, Wuyi Zhang,Weishu Zhu,Eric U Yee,Pamela Suzanne Sears,Xinhua Chen,Ciaran P Kelly

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie（2023）

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摘要

Anti-inflammatory drugs including corticosteroid therapy may worsen the incidence and severity of CDI in this mouse model. These studies may have important clinical implications for understanding the role of anti-inflammatory/ corticosteroid therapy in CDI and inflammatory bowel disease management.

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关键词

C. difficile,Fidaxomicin,Budesonide,Mesalamine

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