Cost-effectiveness analysis of dinutuximab ? for the treatment of high-risk neuroblastoma in China

Background: Dinutuximab ss can be used to treat children with high-risk neuroblastoma (NB). Due to its high price, whether dinutuximab ss is cost-effective for the treatment of high-riskNB remains uncertain. Therefore, assessing the cost-effectiveness of dinutuximab ss in children with high-risk NB is of high importance. Methods: The health utilities and economic outcomes in children with high-risk NB were projected using a partitioned survival model. The individual patient data (IPD) of add-on treatment with dinutuximab ss (GD2 group) were derived from the literature, while the IPD of traditional therapy (TT group) were obtained from retrospective data of Shanghai Children's Medical Center. Treatment costs included drugs, adverse event-related expenses, and medical resource use. Utility values were obtained from the literature. Costs and quality-adjusted life-years (QALYs) were measured over a 10year time horizon. Deterministic sensitivity analyses (DSA) and probabilistic sensitivity analyses (PSA) were also conducted. Results: Compared with the TT group, QALY increased in the GD2 group by 0.72 with an increased cost of $171,269.70, leading to an incremental cost-effectiveness ratio of 236,462.75$/QALY. DSA showed that the price of dinutuximab ss was the main factor on the results than other parameters. Compared with the TT group, the GD2 group could not be cost-effective in the PSA at the $37,920/QALY threshold. Conclusion: Results found that dinutuximab ss is not a cost-effective treatment option for children with high-risk NB unless its price is significantly reduced.