Establishment of a non-lethal model of antibody-dependent enhancement of infection in A129 mice based on a non-mouse-adapted dengue virus strain

Han Wang,Ming-Wang Long, Li Zhang,Yue Pan,Jun-Ying Chen,Kai Feng,Qiang-Ming Sun

ZOOLOGICAL RESEARCH（2023）

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摘要

DEAR EDITOR,Dengue fever（DF）, caused by dengue virus（DENV） infection,is a highly prevalent mosquito-borne infectious disease. The development of antiviral drugs and vaccines relies on the clinical utility of dengue infection models, particularly those involving antibody-dependent enhancement（ADE）. In this study, we co-incubated DENV-2 anti-prM with DENV-3 for 2 h,

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dengue virus strain,a129 mice,non-lethal,antibody-dependent,non-mouse-adapted

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