Glucose fluctuation promotes mitochondrial dysfunctions in the cardiomyocyte cell line HL-1.

Patrick Mordel, Fanny Fontaine, Quentin Dupas,Michael Joubert,Stéphane Allouche

PloS one（2023）

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摘要

Our results demonstrated that exposure of HL-1 cells to glucose swings promoted time-dependent mitochondrial dysfunctions suggesting a deleterious effect of such condition in patients with diabetes that could contribute to diabetic cardiomyopathy.

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关键词

cardiomyocyte cell line,mitochondrial dysfunctions,glucose

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