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Genome‐wide DNA Methylation Sequencing Reveals Epigenetic Features and Potential Biomarkers of Sjögren Syndrome

Ding-qi Lu,Xin-yi Yao,Ya-ting Ren,Kai-yuan Zhang,Xin-chao Zhu,Tao Hong, Xue Yu,Zhi-min Xie,Li-ying Chen,Xin-chang Wang

International Journal of Rheumatic Diseases（2023）

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Abstract
Sjögren syndrome (SS) is a slowly progressive, inflammatory, autoimmune disease. The aim of this study was to construct the DNA methylation profiles of whole blood of SS patients and healthy controls (HC), and to explore the role of differentially methylated genes in the pathogenesis of the disease.
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Key words
diagnostic markers,DNA methylation,epigenetics,Sjogren syndrome,whole-genome bisulfite sequencing
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