Commensal bacteria signal through TLR5 and AhR to improve barrier integrity and prevent allergic responses to food
Cell reports(2023)
摘要
The increasing prevalence of food allergies has been linked to reduced commensal microbial diversity. In this article, we describe two features of allergy-protective Clostridia that contribute to their beneficial effects. Some Clostridial taxa bear flagella (a ligand for TLR5) and produce indole (a ligand for the aryl hydrocarbon receptor [AhR]). Lysates and flagella from a Clostridia consortium induced interleukin-22 (IL-22) secretion from ileal explants. IL-22 production is abrogated in explants from mice in which TLR5 or MyD88 signaling is deficient either globally or conditionally in CD11c(+) antigen-presenting cells. AhR signaling in RORgt(+) cells is necessary for the induction of IL-22. Mice deficient in AhR in RORgt(+) cells exhibit increased intestinal permeability and are more susceptible to an anaphylactic response to food. Our findings implicate TLR5 and AhR signaling in a molecular mechanism by which commensal Clostridia protect against allergic re-sponses to food.
更多查看译文
关键词
allergic responses,tlr5,bacteria
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要