Modulation of PPAR-γ, SREBP-1c and Inflammatory Mediators by Luteolin Ameliorates Β-Cell Dysfunction and Renal Damage in a Rat Model of Type-2 Diabetes Mellitus

Natural products have been recommended as a complementary therapy for type 2 diabetes mellitus (T2DM) due to constraints of safety and tolerability of existing anti-diabetic agents. Luteolin exhibits anti-diabetic and anti-inflammatory effects. Hence, the impact of luteolin on glucose homoeostasis and organ damage was investigated in high-fat diet (HFD) and streptozotocin (STZ) induced T2DM in rats. Male Wistar rats were maintained on HFD (provided 55