N-(((1S,5R)-6,6-Dimethylbicyclo[3.1.1]hept-2-en-2-y l)methyl)-3-dodecan/tetradecanamido-N,N-dimethylpropan-1-a minium Bromide

The syntheses of the title compounds were performed using lauric and myristic acids. The compounds obtained were characterized using H-1-, C-13-NMR and 2D H-1-H-1 COSY, H-1-C-13 HSQC NMR, IR, and high-resolution mass spectrometry. Both compounds exhibited bactericidal activity on S. aureus comparable to that of a reference drug (miramistin). Compound 10, with lauric acid fragment, had a 16-fold higher activity on P. aeruginosa compared to compound 11, which in turn contains myristic acid fragment (with minimum inhibitory concentrations of 32 and 512 mu g/mL, respectively). Compound 11 exhibited a pronounced activity against all types of fungi (higher than the activity of miramistin), while the activity of compound 10 was considerably lower. Thus, compound 11 can serve as a promising antimicrobial agent for the treatment of various fungal and staphylococcal infections, while compound 10 is of interest to treat P. aeruginosa-associated infections.Report this publication