Identifying potential immuno-oncology targets in salivary gland mucoepidermoid carcinoma based on inflammatory status and treatment response.

Santhosh Kumar J Urumarudappa,Vy Ngoc Thuy Tran, Hay Mar Oo,Monthira Suntiparpluacha,Somponnat Sampattavanich,Vinicius Rosa,Komkrit Ruangritchankul,Joao N Ferreira,Risa Chaisuparat

Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology（2023）

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摘要

This preliminary report unveils the importance of assessing immune leukocyte cellular fractions and pathways for future prognostic biomarker discoveries in mucoepidermoid carcinoma as per the involvement of CD45-driven inflammatory and immune mediators in high grade mucoepidermoid carcinoma in non-responders to treatment. These findings will potentially contribute to the development of novel personalised immunotherapies.

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CD45, mucoepidermoid carcinoma, salivary glands, tumour immune evasion, tumour microenvironment

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