Identifying the effectiveness of 3D culture systems to recapitulate breast tumor tissue in situ.

Katarzyna A Ludwik,Frances R Greathouse,Samuel Han,Kimberly Stauffer,David R Brenin,Thomas P Stricker,Deborah A Lannigan

Cellular oncology (Dordrecht)（2023）

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摘要

Our methodology, which focuses on quantifiable cellular phenotypes, provides a tractable system that complements omics approaches to provide an unprecedented view of heterogeneity and will enhance the identification of novel therapies and facilitate personalized medicine.

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关键词

Breast cancer, Heterogeneity, Chemotherapy, Organoid, HER1, Estrogen receptor alpha, Microenvironment

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