Effectiveness of a low trough serum concentration of vancomycin on acute kidney injury in infants and toddlers in the paediatric intensive care unit.

Patients with a vancomycin trough concentration of 4-5 mg/L in the PICU had a high cure rate (79.4%) and a low incidence of acute kidney injury (HR 18.3, 95% CI 5.135 to 87.621; p<0.001). Therefore, the serum trough concentration should be considered but it should also be combined with the treatment effect to achieve individualised administration for the clinical application of vancomycin.