Curcuminoid Chalcones: Synthesis and Biological Activity against the Human Colon Carcinoma (Caco-2) Cell Line.

Dorota Olender,Katarzyna Sowa-Kasprzak,Anna Pawełczyk,Bartosz Skóra,Lucjusz Zaprutko,Konrad A Szychowski

Current medicinal chemistry（2023）

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摘要

The results suggested that compound 3a increased the metabolism and/or proliferation of the human colon carcinoma (Caco-2) cell line, while compounds 3b and 3f showed significant toxicity against the Caco-2 cell line. Overall, the preliminary results suggested that compound 3b exhibited the most favorable anticancer activity.

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