Fungal Depletion Bolsters Anti-Tumor Immune Response Elicited by Anti-PD1 Alone and in Combination with Radiation Therapy.

S Stevens,J K Jang,K Kershaw,J Viramontes,T B Dar,A T Nguyen,R Henson,J Guarnerio,D Underhill,S L Shiao

International journal of radiation oncology, biology, physics（2023）

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摘要

Our data indicates that the depletion of the gut fungal populations induces an increased antitumor response following anti-PD1 alone and in combination with radiation. This increased antitumor immune response is associated with an increase in the cytotoxic CD8+ T cell compartment with concomitant decrease in immunosuppressive tumor associated macrophages.

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