Long-Term Outcomes of NRG/RTOG 0126, a Randomized Trial of High Dose (79.2 Gy) vs. Standard Dose (70.2 Gy) Radiation Therapy (RT) for Men with Localized Prostate Cancer

J. M. Michalski,J. Moughan,J. A. Purdy,D. W. Bruner,M. Amin,J. P. Bahary,H. Lau, M. Duclos, D. Yee,G. Morton,R. T. Dess, D. E. Doncals,M. I. Lock,H. Lukka, B. C. Baumann,E. Vigneault, Y. Kwok, J. Robertson, D. L. Schwartz,H. M. Sandler

International journal of radiation oncology, biology, physics（2023）

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摘要

Long term follow up confirms no improvement in OS with dose escalation in this study population. However, there are significant improvements in ABF, PBF, DM, LP, and need for salvage therapy. Despite the use of more salvage therapy in the low dose arm, dose escalated RT resulted in lower rates of DM, a clinically relevant endpoint. Patients receiving dose escalation do experience a higher rate of grade 2+ GU and GI toxicity but no worse grade 3+ toxicities.

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关键词

prostate cancer,radiation therapy,standard dose,high dose,nrg/rtog,long-term

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