Neoantigen Cancer Vaccine for Immunologically Cold Microsatellite-stable Colorectal Cancer.

K. C. Y. Huang, C. Y. Lee, C. H. Wu, C. Y. Sung,W. T. L. Chen,T. W. Ke,J. A. Liang, C. Y. Lai, W. Z. Hong, E. Y. Chuang,K. S. C. Chao

International Journal of Radiation OncologyBiologyPhysics（2023）

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摘要

Neoantigens identified by our NeoDiVa platform, via the combination of radiotherapy and a novel AAV vaccine delivery system, boosted antigen-specific T-cell function and improve tumor control of limnologically "cold" MSS colorectal cancer in vivo. We are in the process of obtaining an IND and initiating Phase I/II clinical trial to validate safety and efficacy of these exciting findings.

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关键词

Neoantigens,Tumor Microenvironment,Cancer Immunotherapy,Cancer Immunoediting,Biomarkers for Immunotherapy

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