Prospective Validation of Single Nucleotide Polymorphisms as Predictors of Gastrointestinal, Genitourinary, and Sexual Patient-Reported Outcomes Following Radiotherapy for Prostate Cancer

S. C. Kamran,B. Y. Yeap, Z. Soetan,I. Pompa, S. Muise,J. Cowan, M. Moteabbed, B. L. Silvia, C. C. Olsen,A. L. Zietman,J. A. Efstathiou,D. T. Miyamoto

International journal of radiation oncology, biology, physics（2023）

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摘要

Of the 172 SNPs previously reported to be associated with GI, GU, and/or sexual toxicity after prostate RT, 23% were validated for domain-specific QoL detriment. Ongoing analyses include integrated modeling of dosimetry and SNP data for prediction of toxicities and PRO, and evaluation of potential interactions between RT modality (proton/photon) and QoL-associated SNPs.

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关键词

single nucleotide polymorphisms,prostate cancer,radiotherapy,patient-reported

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