Active fraction of Polyrhachis vicina (Roger) alleviated cerebral ischemia/reperfusion injury by targeting SIRT3-mediated mitophagy and angiogenesis.

Jie Wei,Jiaxiu Xie,Junhui He,Dongmei Li,Dongmei Wei,Yi Li,Xiang Li,Weirong Fang,Guining Wei,Kedao Lai

Phytomedicine : international journal of phytotherapy and phytopharmacology（2023）

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摘要

AFPR promoted angiogenesis through activating mitophagy after cerebral ischemia reperfusion, which might partially involved in the amelioration of SIRT3-mediated regulation on Pink1/Parkin axis. Our study will shed new light on the role of SIRT3 in ischemic brain, especially in regulating mitophagy and angiogenesis after stroke.

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关键词

Central nervous system, Stroke, Cerebral ischemia/reperfusion, Mitophagy, Angiogenesis, Sirtuin 3

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