Pulling Rank with RNA: RANKL Promotes the Association of PGC-1β/RNA Complexes with NCoR/HDAC3 to Activate Gene Expression in Osteoclasts.

In this issue, Abe et al1 report a novel mechanism by which RANKL stimulates osteoclast differentiation and bone resorption through non-coding RNAs that bind PGC-1β and convert the NCoR/HDAC3 co-repressor complex into a co-activator of AP-1- and NFκB-regulated genes.