The Prognostic Value of Visceral Adipose Tissue in Patients Undergoing Transcatheter Aortic Valve Replacement.

In patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR), the prediction of mortality risk is crucial to avoid futile procedures and optimize clinical decision making, preoperative interventions, and follow-up. The knowledge of body composition, within nutritional status assessment, is a key tool in evaluating patient frailty. Indeed, several studies have shown the independent prognostic role of low muscle mass in patients who treated with TAVR. 1 Heidari B Al-Hijji MA Moynagh MR Takahashi N Welle G Eleid M Singh M Gulati R Rihal CS Lerman A. Transcatheter aortic valve replacement outcomes in patients with sarcopaenia. EuroIntervention. 2019; 15: 671-677 Crossref PubMed Google Scholar , 2 Mok M Allende R Leipsic J Altisent OA Del Trigo M Campelo-Parada F DeLarochellière R Dumont E Doyle D Côté M Freeman M Webb J Rodés-Cabau J. Prognostic value of fat mass and skeletal muscle mass determined by computed tomography in patients who underwent transcatheter aortic valve implantation. Am J Cardiol. 2016; 117: 828-833 Abstract Full Text Full Text PDF PubMed Google Scholar , 3 Gallone G Depaoli A D'Ascenzo F Tore D Allois L Bruno F Casale M Atzeni F De Lio G Bocchino PP Piroli F Angelini F Angelini A Scudeler L De Lio F Andreis A Salizzoni S La Torre M Conrotto F Rinaldi M Fonio P De Ferrari GM Impact of computed-tomography defined sarcopenia on outcomes of older adults undergoing transcatheter aortic valve implantation. J Cardiovasc Comput Tomogr. 2022; 16: 207-214 Abstract Full Text Full Text PDF Scopus (0) Google Scholar Conversely, the effects of visceral adipose tissue (VAT), a proinflammatory and metabolically active organ associated with unfavorable cardiovascular outcomes, are still poorly explored. Computed tomography (CT), an examination routinely performed in TAVR candidates for evaluating aortic root anatomy and access route, represents the gold standard to measure body composition compartments through the analysis of CT scans at the third lumbar vertebra level using a dedicated software. 2 Mok M Allende R Leipsic J Altisent OA Del Trigo M Campelo-Parada F DeLarochellière R Dumont E Doyle D Côté M Freeman M Webb J Rodés-Cabau J. Prognostic value of fat mass and skeletal muscle mass determined by computed tomography in patients who underwent transcatheter aortic valve implantation. Am J Cardiol. 2016; 117: 828-833 Abstract Full Text Full Text PDF PubMed Google Scholar ,3 Gallone G Depaoli A D'Ascenzo F Tore D Allois L Bruno F Casale M Atzeni F De Lio G Bocchino PP Piroli F Angelini F Angelini A Scudeler L De Lio F Andreis A Salizzoni S La Torre M Conrotto F Rinaldi M Fonio P De Ferrari GM Impact of computed-tomography defined sarcopenia on outcomes of older adults undergoing transcatheter aortic valve implantation. J Cardiovasc Comput Tomogr. 2022; 16: 207-214 Abstract Full Text Full Text PDF Scopus (0) Google Scholar This study aimed to investigate the prognostic role of CT-measured VAT in patients undergoing TAVR.