Diurnal circadian clock gene expression is altered in models of genetic and acquired epilepsy.

Glenn R Yamakawa,Meshwa Patel,Runxuan Lin, Terence J O'Brien,Richelle Mychasiuk,Pablo M Casillas-Espinosa

Epilepsia open（2023）

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摘要

These results indicate marked diurnal disruption to core circadian clock gene expression in rats with both generalized and focal chronic epilepsy. This could contribute to epileptic symptomology and implicate the circadian system as a viable target for future treatments.

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关键词

animal model, bmal1, circadian, cry1, GAERS, per1, post-SE, seizure, sleep

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