Photo-Responsive Ovalbumin-Loaded MnO2 Nanoparticles for Enhanced T-1-Magnetic Resonance Imaging and Immunotherapy of Cancer

Photo-responsive combinational therapeutics attained significant attention in cancer theranostic owing to the versatile features of nanomaterials. The simplest nano-design with unique properties to carry out multifunctionalties is a challenging assignment. Herein, a facile solvothermal method is employed to fabricate homogeneous MnO2 sea urchin-shaped nanoparticles (MnO2-OVA NPs) with a high loading capacity (86.15%) of ovalbumin (OVA) antigen. The prepared MnO2-OVA NPs demonstrated excellent biocompatibility against different cell lines and significant cellular uptake, resulting in mature dendritic cells to enhance anti-tumor immunity. The synthesized sea urchin-shaped MnO2-OVA NPs further exhibited self-generated catalytic properties that efficiently relieve tumor hypoxia and improve cancer therapies. More excitingly, MnO2-OVA NPs endorsed reactive oxygen species (ROS) in response of minute UV irradiation (mW) for photodynamic therapy. Further, the prepared photo-responsive nanoparticles showed promising T1-MR imaging and relaxivity properties for diagnosis and real-time drug delivery monitoring. These synergetic therapeutic strategies produced by MnO2-OVA NPs showed excellency as a potential theranostic agent.