Mobile-based multimodal rehabilitation including exercise, nutritional, and psychological interventions in patients with abdominal cancer receiving concurrent chemoradiotherapy: Prospective, multicenter, randomized trial

e24138 Background: Concurrent chemoradiotherapy (CCRT) has several adverse toxicities such as fatigue, bone marrow suppression and malnutrition. We aimed to examine whether the mobile-based multimodal rehabilitation including exercise, nutritional and psychological interventions have an impact on clinical outcomes in abdominal cancer patients receiving concurrent chemoradiotherapy. Methods: A total of 90 eligible abdominal cancer patients were randomly assigned (1:1) to either the study (n = 47) or control (n = 43) group from February 2022 to November 2022. Multimodal rehabilitation was provided by a team of oncologists, rehabilitation physicians, nurses, clinical nutritionists and psychologists, while patients in the control group received only standard oncologic care. The study group received a wearable device and mobile app that provided an exercise program (at least 90 to 150 minutes of aerobic and resistance exercise per week for 5 weeks, depending on the patient's health status). Primary endpoints were changes in grip strength and body weight, with secondary endpoints including nutrition-related haematological indicators, toxicity and treatment completion rate. Results: Our study found that the body weight and grip strength of patients in the control group decreased significantly after CCRT, while those in the study group remained stable. The average weight loss (-0.19 ± 1.51 kg vs 1.28±1.90 kg, P = 0.016) and average grip strength loss (-0.95 ± 2.24 vs 1.26 ± 2.38 kg, P = 0.008) in the study group and control group after CCRT were significantly different. Meanwhile, patients in the study group showed less decline in haemoglobin levels (-1.96 ± 10.24 vs 12.05 ± 8.45 g/L, P = 0.000), serum albumin levels (0.65 ± 4.40 g/L vs 3.42 ± 2.87 g/L, P = 0.030) and lymphocyte count (0.74 ± 0.30 vs 1.16 ± 0.62 g/L, P = 0.010) contrast with control group. Conclusions: Multimodal rehabilitation based on mobile health could effectively maintain the body weight and nutritional status of patients undergoing concurrent chemoradiotherapy, which may be beneficial to improve the treatment tolerance of patients. Keywords: Abdominal cancer; Concurrent chemoradiotherapy; Multimodal rehabilitation; Mobile health; Grip strength. Clinical trial information: NCT05325554 .