Recombinant human diamine oxidase prevents hemodynamic effects of continuous histamine infusion in guinea pigs.

Matthias Weiss-Tessbach,Birgit Reiter,Elisabeth Gludovacz,Thomas Boehm,Bernd Jilma,Marlene Rager-Resch

Inflammation research : official journal of the European Histamine Research Society ... [et al.]（2023）

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摘要

Prophylactic infusion of rhDAO_mHBM prevents hemodynamic effects in a guinea pig model of continuous histamine infusion. These findings might help in the translation from animals to humans and in the selection of the optimal dosing of rhDAO_mHBM during human histamine challenge studies.

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关键词

(MeSH terms), Amine oxidase (Copper-containing), Diamines, Rodents, Heart rate, Blood pressure, Body temperature

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