Flavonoids from Smilax china L. Rhizome improve chronic pelvic inflammatory disease by promoting macrophage reprogramming via the NLRP3 inflammasome-autophagy pathway

Yun Ma,Tingting Pei,Luyao Song,Daoqi Zhu,Zhongxiao Han,Jiaxing Zhang,Xintao Huang, Xinhuan Qiu,Wei Xiao

Journal of Functional Foods（2023）

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摘要

•Smilax china L. is used to treat chronic pelvic inflammatory diseases (CPIDs).•Flavonoids from S. china rhizome (FSCR) improve CPID by inhibiting inflammation.•FSCR target VPS34 to promote autophagic cell reprogramming.•FSCR ameliorates CPID via the NLRP3 inflammasome-related autophagy pathway.

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关键词

Flavonoid extract of Smilax china L., Chronic pelvic inflammation, Macrophage reprogramming, Inflammasome, Autophagy

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