Adeno-associated virus-vectored erythropoietin gene therapy for anemia in cats with chronic kidney disease.

Shelly L Vaden,Allison R Kendall,Jonathan D Foster, Heidi L New,Jane S Eagleson, Jacky L May,Anne M Traas,Matthew J Wilson, Beth H McIntyre,Christian J Hinderer,Lauren K Olenick,James M Wilson

Journal of veterinary internal medicine（2023）

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摘要

Results of this study suggest that SB-001 therapy represents a suitable single injection treatment that can address nonregenerative anemia in cats with CKD. It was generally well tolerated; however, hypertension and encephalopathy developed in some cats as previously described in association with erythropoiesis-stimulating agent therapy.

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关键词

AAV, cats, red blood cells, renal disease

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