Case Report: Acute Kidney Injury As the Initial Manifestation of Chronic Lymphocytic Leukemia/small Lymphocytic Lymphoma.
Frontiers in medicine(2023)
摘要
Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disorder often diagnosed after incidental finding of leukocytosis. Renal involvement is usually clinically silent. Symptomatic renal impairment due to CLL/small lymphocytic lymphoma (SLL) cell infiltration in the kidney tissue is uncommon, and acute kidney injury (AKI) as a presenting feature is rare. In this case report, we describe the case of a patient with AKI caused by CLL/SLL infiltration as a presenting feature. Our report highlights the possibility of kidney injury as the first evident symptom of CLL/SLL. Kidney biopsy is the mainstay in these cases in order to establish a diagnosis. Treatment with zanubrutinib resulted in improved kidney function.
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关键词
chronic lymphocytic leukemia/small lymphocytic lymphoma,kidney involvement,infiltration,extranodal,zanubrutinib acute kidney injury as initial manifestation of chronic lymphocytic leukemia/small lymphocytic lymphoma,paraprotein
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