A convenient synthesis of new phosphonomethyl-containing 4,5-dihydropyridazin-3(2H)-ones

Oumayma Bejaoui,Abderrahmen Abdelli,Hedi M'rabet,Xavier Moreau,Mohamed Lotfi Efrit,Damien Prim

Mendeleev Communications（2023）

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摘要

An expedient access to novel 4-phosphonomethyl-containing 2,6-disubstituted 4,5-dihydropyridazin-3(2H)-ones involves the reaction of β-phosphono γ'-keto ester intermediates with hydrazines. The construction of the pyridazinone ring allows the installation of various substituents at the positions 2 and 6 as well as a valuable 4-positioned phosphonomethyl fragment.

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关键词

pyridazin-3(2H)-ones,phosphonates,nitroalkanes,γ-keto ester,Michael addition,Nef reaction

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