Risk Prediction Models for Hospital Mortality in General Medical Patients: A Systematic Review

•The performance and validity of hospital mortality prediction models in general medical patients have not been well appraised.•Hospital mortality prediction models were either developed or validated in all general medical patients or those with infection.•Both general and infection models had high risk of bias with variable performance. No models have been well validated to ensure generalizability and stability of performance.•Further validated models are required to predict mortality and guide mortality reduction interventions.