Restriction of Arginine Induces Antibiotic Tolerance in Staphylococcus aureus .

Methicillin-Resistant (MRSA) is a leading bacterial cause of morbidity and mortality worldwide. Despite the availability of numerous antibiotics with efficacy against MRSA, there are still high rates of antibiotic treatment failure in infections, suggesting antibiotic tolerance is common during human infections. Here, we report a direct connection between the metabolism of arginine, an essential amino acid in , and tolerance to multiple classes of antibiotics. This represents a key pathway towards broad antibiotic tolerance in and therefore an attractive target to help repotentiate current antibiotics and potentially reduce treatment failure.