Head & Neck Oncology Track: Subsite-Specific Transcriptional Networks in Oral Squamous Cell Carcinoma May Allow for Subsite-Directed Therapies

Head and neck squamous cell carcinoma (HNSCC), in particular in oral cavity cancer, continues to pose a challenge to obtaining locoregional control and survival. Currently, there is a poor understanding of the HNSCC disease biology. While the depth of invasion and T-stage are the focus of clinical decision-making, molecular biology may yield additional actionable information. We sought to identify key oncogenic transcriptional networks within different anatomical subsites that correlate with tumor stage and survival outcome.